PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD
limepiride is an oral antidiabetic drugs which is practically insoluble in water. The formation of β-cyclodextrin inclusion complex was able to increase the solubility of glimepiride. This study aim to prepare, characterize and formulation of inclusion complex tablets in order to meet the requiremen...
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2015-05-01
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| Series: | Indonesian Journal of Pharmacy |
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| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/779 |
| _version_ | 1811203048324726784 |
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| author | Yandi Syukri* Laryssa Fernenda, issy Rizki Utami, Isna Qiftayati Aris Perdana Kusuma Rochmy Istikaharah |
| author_facet | Yandi Syukri* Laryssa Fernenda, issy Rizki Utami, Isna Qiftayati Aris Perdana Kusuma Rochmy Istikaharah |
| author_sort | Yandi Syukri* |
| collection | DOAJ |
| description | limepiride is an oral antidiabetic drugs which is practically insoluble in water. The formation of β-cyclodextrin inclusion complex was able to increase the solubility of glimepiride. This study aim to prepare, characterize and formulation of inclusion complex tablets in order to meet the requirement in Pharmacopeia. The inclusion complex were prepared in a molar ratio of 1:1 and 1:2 by freeze drying method, afterthat characterized include FTIR spectroscopy and scanning electro microscope (SEM). Further, it was formulated into tablets by direct compression technique using primogel and crospovidone as superdisintegrants. The tablets were evaluated include weight uniformity, hardness, friability, disintegration, and dissolution. The dissolution studies of inclusion complex were performed by using USP II apparatus. The result of FTIR and SEM provided evidence of the formation of complexes after utilizing freeze-drying methods. The tablet evaluation containing inclusion complex glimepiride-β cyclodextrin with primogel and cropovidone as disintegrant showed that increased concentration of disintegrant will increase disintegration time of the tablets. All of formulas meet the requirements in the Pharmacopoeia. The inclusion complex of glimepiride–β cyclodextrin successfully used for enhancing the solubility of glimepiride and the tablets meet the requirement in Pharmacopeia. |
| first_indexed | 2024-04-12T02:48:42Z |
| format | Article |
| id | doaj.art-7da146a15c7349a5b1598154a845d11d |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-04-12T02:48:42Z |
| publishDate | 2015-05-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-7da146a15c7349a5b1598154a845d11d2022-12-22T03:51:04ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862015-05-012627177PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHODYandi Syukri*0Laryssa Fernenda,1issy Rizki Utami,2Isna Qiftayati3Aris Perdana Kusuma4Rochmy Istikaharah5Department of Pharmacy, Universitas Islam Indonesia, Jalan Kaliurang KM 14,5 Sleman Yogyakarta, 55584, IndonesiaDepartment of Pharmacy, Universitas Islam Indonesia, Jalan Kaliurang KM 14,5 Sleman Yogyakarta, 55584, IndonesiaDepartment of Pharmacy, Universitas Islam Indonesia, Jalan Kaliurang KM 14,5 Sleman Yogyakarta, 55584, IndonesiaDepartment of Pharmacy, Universitas Islam Indonesia, Jalan Kaliurang KM 14,5 Sleman Yogyakarta, 55584, IndonesiaDepartment of Pharmacy, Universitas Islam Indonesia, Jalan Kaliurang KM 14,5 Sleman Yogyakarta, 55584, IndonesiaDepartment of Pharmacy, Universitas Islam Indonesia, Jalan Kaliurang KM 14,5 Sleman Yogyakarta, 55584, Indonesialimepiride is an oral antidiabetic drugs which is practically insoluble in water. The formation of β-cyclodextrin inclusion complex was able to increase the solubility of glimepiride. This study aim to prepare, characterize and formulation of inclusion complex tablets in order to meet the requirement in Pharmacopeia. The inclusion complex were prepared in a molar ratio of 1:1 and 1:2 by freeze drying method, afterthat characterized include FTIR spectroscopy and scanning electro microscope (SEM). Further, it was formulated into tablets by direct compression technique using primogel and crospovidone as superdisintegrants. The tablets were evaluated include weight uniformity, hardness, friability, disintegration, and dissolution. The dissolution studies of inclusion complex were performed by using USP II apparatus. The result of FTIR and SEM provided evidence of the formation of complexes after utilizing freeze-drying methods. The tablet evaluation containing inclusion complex glimepiride-β cyclodextrin with primogel and cropovidone as disintegrant showed that increased concentration of disintegrant will increase disintegration time of the tablets. All of formulas meet the requirements in the Pharmacopoeia. The inclusion complex of glimepiride–β cyclodextrin successfully used for enhancing the solubility of glimepiride and the tablets meet the requirement in Pharmacopeia.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/779Glimepiridβ-cyclodextrinprimogel |
| spellingShingle | Yandi Syukri* Laryssa Fernenda, issy Rizki Utami, Isna Qiftayati Aris Perdana Kusuma Rochmy Istikaharah PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD Indonesian Journal of Pharmacy Glimepirid β-cyclodextrin primogel |
| title | PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD |
| title_full | PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD |
| title_fullStr | PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD |
| title_full_unstemmed | PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD |
| title_short | PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD |
| title_sort | preperation and characterization of β cyclodextrin inclusion complexes oral tablets containing poorly water soluble glimipiride using freeze drying method |
| topic | Glimepirid β-cyclodextrin primogel |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/779 |
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