<i>Ecklonia cava</i> Extract and Its Derivative Dieckol Promote Vasodilation by Modulating Calcium Signaling and PI3K/AKT/eNOS Pathway in In Vitro and In Vivo Models

<i>Ecklonia cava</i> Extract and Its Derivative Dieckol Promote Vasodilation by Modulating Calcium Signaling and PI3K/AKT/eNOS Pathway in In Vitro and In Vivo Models

Nitric oxide (NO), an endothelial-derived relaxing factor synthesized by endothelial nitric oxide synthase (eNOS) in endothelial cells, enhances vasodilation by modulating vascular tone. The calcium concentration critically influences eNOS activation in endothelial cells. Thus, modulation of calcium...

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Bibliographic Details
Main Authors: Yu-An Lu, Jun-Geon Je, Jin Hwang, You-Jin Jeon, BoMi Ryu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Biomedicines
Subjects:
<i>Ecklonia cava</i>
dieckol
NO production
calcium transit
M3 muscarinic acetylcholine receptor
endothelial cell
Online Access:https://www.mdpi.com/2227-9059/9/4/438

Internet

https://www.mdpi.com/2227-9059/9/4/438

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