G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis

Rare variants in the G-protein coupled receptor 151 (GPR151) gene in humans are associated with lower odds ratio for type 2 diabetes, but the mechanism behind this association has remained elusive. Here, the authors show that GPR151 regulates the process of hepatic gluconeogenesis and affects whole-...

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Bibliographic Details
Main Authors: Ewa Bielczyk-Maczynska, Meng Zhao, Peter-James H. Zushin, Theresia M. Schnurr, Hyun-Jung Kim, Jiehan Li, Pratima Nallagatla, Panjamaporn Sangwung, Chong Y. Park, Cameron Cornn, Andreas Stahl, Katrin J. Svensson, Joshua W. Knowles
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35069-9

Internet

https://doi.org/10.1038/s41467-022-35069-9

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