A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo

We describe, for the first time, a new splice variant of the human TGF-β type II receptor (TβRII). The new transcript lacks 149 nucleotides, resulting in a frameshift and the emergence of an early stop codon, rendering a truncated mature protein of 57 amino acids. The predicted protein, lacking the...

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Bibliographic Details
Main Authors: Marcela Soledad Bertolio, Anabela La Colla, Alejandra Carrea, Ana Romo, Gabriela Canziani, Stella Maris Echarte, Sabrina Campisano, German Patricio Barletta, Alexander Miguel Monzon, Tania Melina Rodríguez, Andrea Nancy Chisari, Ricardo Alfredo Dewey
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
soluble receptor
peptibody
TGF-beta
fusion protein
organ fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.690397/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.690397/full

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