The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants

The Novel Synthetic Antibiotic BDTL049 Based on a Dendritic System Induces Lipid Domain Formation while Escaping the Cell Envelope Stress Resistance Determinants

The threat of antimicrobial-resistant bacteria is ever increasing and over the past-decades development of novel therapeutic counter measurements have virtually come to a halt. This circumstance calls for interdisciplinary approaches to design, evaluate and validate the mode of action of novel antib...

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Bibliographic Details
Main Authors: Philipp F. Popp, Tania Lozano-Cruz, Franziska Dürr, Addis Londaitsbehere, Johanna Hartig, Francisco Javier de la Mata, Rafael Gómez, Thorsten Mascher, Ainhoa Revilla-Guarinos
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
drug design
click chemistry
mode of action
cell envelope stress response
carbosilane dendritic system
<i>Bacillus subtilis</i>
Online Access:https://www.mdpi.com/1999-4923/15/1/297

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https://www.mdpi.com/1999-4923/15/1/297

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