Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma

Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma

Abstract Background Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of selected immunogenic drugs and immunotherapy to sensitize poorly T-cel...

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Bibliographic Details
Main Authors: Valeria Lucarini, Ombretta Melaiu, Silvia D’Amico, Fabio Pastorino, Patrizia Tempora, Marco Scarsella, Marco Pezzullo, Adele De Ninno, Valentina D’Oria, Michele Cilli, Laura Emionite, Paola Infante, Lucia Di Marcotullio, Maria Antonietta De Ioris, Giovanni Barillari, Rita Alaggio, Luca Businaro, Mirco Ponzoni, Franco Locatelli, Doriana Fruci
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Neuroblastoma
Immunotherapy
Tumor Microenvironment
Immunomodulation
Drug Evaluation
Online Access:https://doi.org/10.1186/s13046-022-02525-9

Internet

https://doi.org/10.1186/s13046-022-02525-9

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