Modification of cyclic NGR tumor neovasculature-homing motif sequence to human plasminogen kringle 5 improves inhibition of tumor growth.

Modification of cyclic NGR tumor neovasculature-homing motif sequence to human plasminogen kringle 5 improves inhibition of tumor growth.

BACKGROUND: Blood vessels in tumors express higher level of aminopeptidase N (APN) than normal tissues. Evidence suggests that the CNGRC motif is an APN ligand which targets tumor vasculature. Increased expression of APN in tumor vascular endothelium, therefore, offers an opportunity for targeted de...

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Bibliographic Details
Main Authors: Weiwei Jiang, Guanghui Jin, Dingyuan Ma, Feng Wang, Tong Fu, Xiao Chen, Xiwen Chen, Kunzhi Jia, Faiz M M T Marikar, Zichun Hua
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3349653?pdf=render

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http://europepmc.org/articles/PMC3349653?pdf=render

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