Periodontitis Induced by P. gingivalis-LPS Is Associated With Neuroinflammation and Learning and Memory Impairment in Sprague-Dawley Rats

Periodontitis Induced by P. gingivalis-LPS Is Associated With Neuroinflammation and Learning and Memory Impairment in Sprague-Dawley Rats

BackgroundPeriodontitis is one of the most common oral diseases and is a potential risk factor for systemic diseases. In this study, we aimed to investigate the association between periodontitis and learning and memory impairment.MethodsWe established a periodontitis model by topical application of...

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Bibliographic Details
Main Authors: Yi Hu, Huxiao Li, Jing Zhang, Xu Zhang, Xinyi Xia, Che Qiu, Yue Liao, Huiwen Chen, Zhongchen Song, Wei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Neuroscience
Subjects:
periodontitis
neuroinflammation
learning and memory impairment
APP processing
TLR4/NF-κB signaling pathway
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00658/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00658/full

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