Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions

Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions

Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death. Our previous studies showed that CDK5 knockdown (KD) in astrocyt...

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Bibliographic Details
Main Authors: Luisa Fernanda Toro-Fernández, Juan Camilo Zuluaga-Monares, Ana María Saldarriaga-Cartagena, Gloria Patricia Cardona-Gómez, Rafael Posada-Duque
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
astrocyte
calcium homeostasis
CDK5
excitotoxicity
synaptic protein
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.643717/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.643717/full

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