Trophoblast stem cell-based organoid models of the human placental barrier

Abstract Human placental villi have essential roles in producing hormones, mediating nutrient and waste exchange, and protecting the fetus from exposure to xenobiotics. Human trophoblast organoids that recapitulate the structure of villi could provide an important in vitro tool to understand placent...

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Bibliographic Details
Main Authors: Takeshi Hori, Hiroaki Okae, Shun Shibata, Norio Kobayashi, Eri H. Kobayashi, Akira Oike, Asato Sekiya, Takahiro Arima, Hirokazu Kaji
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45279-y