GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment

GRHL2 suppression of NT5E/CD73 in breast cancer cells modulates CD73-mediated adenosine production and T cell recruitment

Summary: Tumor tissues often contain high extracellular adenosine, promoting an immunosuppressed environment linked to mesenchymal transition and immune evasion. Here, we show that loss of the epithelial transcription factor, GRHL2, triggers NT5E/CD73 ecto-enzyme expression, augmenting the conversio...

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Những tác giả chính: Bircan Coban, Zi Wang, Chen-yi Liao, Klara Beslmüller, Mieke A.M. Timmermans, John W.M. Martens, Jasmijn H.M. Hundscheid, Bram Slutter, Annelien J.M. Zweemer, Elsa Neubert, Erik H.J. Danen
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Elsevier 2024-05-01
Loạt:iScience
Những chủ đề:
Molecular biology
Immunology
Cell biology
Cancer
Truy cập trực tuyến:http://www.sciencedirect.com/science/article/pii/S258900422400960X

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http://www.sciencedirect.com/science/article/pii/S258900422400960X

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