Molecular Mechanism of Hippo–YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration

Molecular Mechanism of Hippo–YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration

The Hippo–YAP1/TAZ pathway is a highly conserved central mechanism that controls organ size through the regulation of cell proliferation and other physical attributes of cells. The transcriptional factors Yes-associated protein 1 (YAP1) and PDZ-binding motif (TAZ) act as downstream effectors of the...

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Bibliographic Details
Main Authors: Xiaoqing Chen, Yilang Li, Jiandong Luo, Ning Hou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
YAP1/TAZ
Hippo pathway
post-translational modification
heart development
cardiac disease
regeneration
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00389/full

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https://www.frontiersin.org/article/10.3389/fphys.2020.00389/full

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