The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current

The Anti-Epileptic Drugs Lamotrigine and Valproic Acid Reduce the Cardiac Sodium Current

Anti-epileptic drugs (AEDs) are associated with increased risk of sudden cardiac death. To establish whether gabapentin, lamotrigine, levetiracetam, pregabalin, and valproic acid reduce the Na<sub>v</sub>1.5 current, we conducted whole-cell patch-clamp studies to study the effects of the...

Full description

Bibliographic Details
Main Authors: Lixia Jia, Arie O. Verkerk, Hanno L. Tan
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
anti-epileptic drugs
sudden cardiac death
cardiomyocytes
sodium current
action potentials
Online Access:https://www.mdpi.com/2227-9059/11/2/477

Internet

https://www.mdpi.com/2227-9059/11/2/477

Similar Items