GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation

GABAergic and glutamatergic inputs to the medulla oblongata and locus coeruleus noradrenergic pathways are critical for seizures and postictal antinociception neuromodulation

Abstract We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS GABAergic interneurons and noradrenergic pathways from the locus coeruleus (LC) in these phenomena. The...

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Bibliographic Details
Main Authors: Marcelo Mendonça-dos-Santos, Thaís Cristina Teixeira Gonçalves, Luiz Luciano Falconi-Sobrinho, Tayllon dos Anjos-Garcia, Ivair Matias, Rithiele Cristina de Oliveira, Maria de Fátima dos Santos Sampaio, Fabrízio dos Santos Cardoso, Wagner Ferreira dos Santos, Helio Rubens Machado, Norberto Cysne Coimbra
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Refractory epilepsy
Tonic‒clonic seizures
Nucleus of the tractus solitarius
NMDA receptor
GABAA receptor
Locus coeruleus
Online Access:https://doi.org/10.1038/s41598-024-53744-3

Internet

https://doi.org/10.1038/s41598-024-53744-3

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