Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas

Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain areas

Abstract Background Under inflammatory conditions, the activation of corticotropin-releasing factor (CRF) receptor has been shown to inhibit pain through opioid peptide release from immune cells or neurons. CRF’s effects on human and animal pain modulation depend, however, on the distribution of its...

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Bibliographic Details
Main Authors: Shaaban A. Mousa, Baled I. Khalefa, Mohammed Shaqura, Mohammed Al-Madol, Sascha Treskatsch, Michael Schäfer
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Neuroinflammation
Subjects:
Inflammatory pain
Corticotropin-releasing factor
Brain
Opioid peptide
Immunofluorescence
Online Access:https://doi.org/10.1186/s12974-022-02498-8

Internet

https://doi.org/10.1186/s12974-022-02498-8

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