Highly Purified Alloantigen-Specific Tregs From Healthy and Chronic Kidney Disease Patients Can Be Long-Term Expanded, Maintaining a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines

Highly Purified Alloantigen-Specific Tregs From Healthy and Chronic Kidney Disease Patients Can Be Long-Term Expanded, Maintaining a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines

The adoptive transfer of alloantigen-specific regulatory T cells (alloTregs) has been proposed as a therapeutic alternative in kidney transplant recipients to the use of lifelong immunosuppressive drugs that cause serious side effects. However, the clinical application of alloTregs has been limited...

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Bibliographic Details
Main Authors: Arimelek Cortés-Hernández, Evelyn Katy Alvarez-Salazar, Saúl Arteaga-Cruz, Katya Rosas-Cortina, Nadyeli Linares, Josefina M. Alberú Gómez, Gloria Soldevila
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
transplantation
regulatory T cells
allospecific
expansion
suppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.686530/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.686530/full

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