A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression

A Combination of Conformation-Specific RAF Inhibitors Overcome Drug Resistance Brought about by RAF Overexpression

Cancer cells often adapt to targeted therapies, yet the molecular mechanisms underlying adaptive resistance remain only partially understood. Here, we explore a mechanism of RAS/RAF/MEK/ERK (MAPK) pathway reactivation through the upregulation of RAF isoform (RAFs) abundance. Using computational mode...

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Bibliographic Details
Main Authors: Hiroaki Imoto, Nora Rauch, Ashish J. Neve, Fahimeh Khorsand, Martina Kreileder, Leonidas G. Alexopoulos, Jens Rauch, Mariko Okada, Boris N. Kholodenko, Oleksii S. Rukhlenko
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomolecules
Subjects:
MAP Kinases
RAF dimerization
RAF inhibitor resistance
structure-based mechanistic modeling
RAF isoforms
ARAF knockout
Online Access:https://www.mdpi.com/2218-273X/13/8/1212

Internet

https://www.mdpi.com/2218-273X/13/8/1212

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