Oct4 cooperates with c-Myc to improve mesenchymal-to-endothelial transition and myocardial repair of cardiac-resident mesenchymal stem cells

Oct4 cooperates with c-Myc to improve mesenchymal-to-endothelial transition and myocardial repair of cardiac-resident mesenchymal stem cells

Abstract Background Cardiac-resident mesenchymal stem cells (cMSCs) can exhibit fibrotic, proinflammatory, and proangiogenic phenotype in response to myocardial ischemia (Isch). How their phenotypic fate decisions are determined remains poorly understood. Here, we demonstrate that the cooperation of...

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Bibliographic Details
Main Authors: Lan Zhao, Jianshuo Wang, Pengzhen Wang, Zhanyu Deng, Jin Cui, Weiguang Huang, Shaoheng Zhang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Stem Cell Research & Therapy
Subjects:
Myocardial Infarct
Angiogenesis
Mesenchymal stem cells
c-Myc
Oct4
Online Access:https://doi.org/10.1186/s13287-022-03120-7

Internet

https://doi.org/10.1186/s13287-022-03120-7

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