Attenuation of Acute Renal Injury After the Post-resuscitation Administration of Doxycycline in Surviving Newborn Piglets With Severe Hypoxia-Reoxygenation

Attenuation of Acute Renal Injury After the Post-resuscitation Administration of Doxycycline in Surviving Newborn Piglets With Severe Hypoxia-Reoxygenation

Background: Asphyxiated neonates often have myocardial dysfunction and renal insufficiency. Previously we demonstrated that doxycycline improved cardio-renal function through matrix metalloproteinase (MMP)-2 inhibition in an acute swine model of neonatal hypoxia-reoxygenation. The prolonged cardio-r...

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Bibliographic Details
Main Authors: Tze-Fun Lee, Min Lu, Matteo P. Pasquin, Georg M. Schmölzer, Po-Yin Cheung
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pediatrics
Subjects:
renal failure
asphyxia
MMP
doxycycline
newborn
Online Access:https://www.frontiersin.org/article/10.3389/fped.2019.00075/full

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https://www.frontiersin.org/article/10.3389/fped.2019.00075/full

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