Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms

Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms

T-cell development in the thymus undergoes the process of differentiation, selective proliferation, and survival from CD4−CD8− double negative (DN) stage to CD4+CD8+ double positive (DP) stage prior to the formation of CD4+ helper and CD8+ cytolytic T cells ready for circulation. Each developmental...

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Bibliographic Details
Main Authors: Xin Wang, Anjun Jiao, Lina Sun, Wenhua Li, Biao Yang, Yanhong Su, Renyi Ding, Cangang Zhang, Haiyan Liu, Xiaofeng Yang, Chenming Sun, Baojun Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
thymocyte
T-cell development
apoptosis
β-selection
Online Access:https://elifesciences.org/articles/75508

Internet

https://elifesciences.org/articles/75508

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