Distinct hepatocyte identities in liver homeostasis and regenerationKey points
Summary: The process of metabolic liver zonation is spontaneously established by assigning distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical metabolic functions, while also maintaining hepatocyte mass by replication when needed. Recent technological adv...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
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| Series: | JHEP Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555923001106 |
| _version_ | 1797781859398057984 |
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| author | Feng Chen Katharina Schönberger Jan S. Tchorz |
| author_facet | Feng Chen Katharina Schönberger Jan S. Tchorz |
| author_sort | Feng Chen |
| collection | DOAJ |
| description | Summary: The process of metabolic liver zonation is spontaneously established by assigning distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical metabolic functions, while also maintaining hepatocyte mass by replication when needed. Recent technological advances have enabled us to fine-tune our understanding of hepatocyte identity during homeostasis and regeneration. Subsets of hepatocytes have been identified to be more regenerative and some have even been proposed to function like stem cells, challenging the long-standing view that all hepatocytes are similarly capable of regeneration. The latest data show that hepatocyte renewal during homeostasis and regeneration after liver injury is not limited to rare hepatocytes; however, hepatocytes are not exactly the same. Herein, we review the known differences that give individual hepatocytes distinct identities, recent findings demonstrating how these distinct identities correspond to differences in hepatocyte regenerative capacity, and how the plasticity of hepatocyte identity allows for division of labour among hepatocytes. We further discuss how these distinct hepatocyte identities may play a role during liver disease. |
| first_indexed | 2024-03-13T00:02:52Z |
| format | Article |
| id | doaj.art-7dd3870b7df1449eb677ddd96ce0060c |
| institution | Directory Open Access Journal |
| issn | 2589-5559 |
| language | English |
| last_indexed | 2024-03-13T00:02:52Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHEP Reports |
| spelling | doaj.art-7dd3870b7df1449eb677ddd96ce0060c2023-07-13T05:30:44ZengElsevierJHEP Reports2589-55592023-08-0158100779Distinct hepatocyte identities in liver homeostasis and regenerationKey pointsFeng Chen0Katharina Schönberger1Jan S. Tchorz2Novartis Institutes for BioMedical Research, Cambridge, MA, United States; Corresponding authors. Addresses: Novartis Institutes for BioMedical Research, Cambridge, MA, United States, or Novartis Institutes for BioMedical Research, Basel, Switzerland.Novartis Institutes for BioMedical Research, Basel, SwitzerlandNovartis Institutes for BioMedical Research, Basel, Switzerland; Corresponding authors. Addresses: Novartis Institutes for BioMedical Research, Cambridge, MA, United States, or Novartis Institutes for BioMedical Research, Basel, Switzerland.Summary: The process of metabolic liver zonation is spontaneously established by assigning distributed tasks to hepatocytes along the porto-central blood flow. Hepatocytes fulfil critical metabolic functions, while also maintaining hepatocyte mass by replication when needed. Recent technological advances have enabled us to fine-tune our understanding of hepatocyte identity during homeostasis and regeneration. Subsets of hepatocytes have been identified to be more regenerative and some have even been proposed to function like stem cells, challenging the long-standing view that all hepatocytes are similarly capable of regeneration. The latest data show that hepatocyte renewal during homeostasis and regeneration after liver injury is not limited to rare hepatocytes; however, hepatocytes are not exactly the same. Herein, we review the known differences that give individual hepatocytes distinct identities, recent findings demonstrating how these distinct identities correspond to differences in hepatocyte regenerative capacity, and how the plasticity of hepatocyte identity allows for division of labour among hepatocytes. We further discuss how these distinct hepatocyte identities may play a role during liver disease.http://www.sciencedirect.com/science/article/pii/S2589555923001106Liver regenerationHepatocyte identityHepatocyte plasticityPloidyLiver stem cellsMetabolic liver zonation |
| spellingShingle | Feng Chen Katharina Schönberger Jan S. Tchorz Distinct hepatocyte identities in liver homeostasis and regenerationKey points JHEP Reports Liver regeneration Hepatocyte identity Hepatocyte plasticity Ploidy Liver stem cells Metabolic liver zonation |
| title | Distinct hepatocyte identities in liver homeostasis and regenerationKey points |
| title_full | Distinct hepatocyte identities in liver homeostasis and regenerationKey points |
| title_fullStr | Distinct hepatocyte identities in liver homeostasis and regenerationKey points |
| title_full_unstemmed | Distinct hepatocyte identities in liver homeostasis and regenerationKey points |
| title_short | Distinct hepatocyte identities in liver homeostasis and regenerationKey points |
| title_sort | distinct hepatocyte identities in liver homeostasis and regenerationkey points |
| topic | Liver regeneration Hepatocyte identity Hepatocyte plasticity Ploidy Liver stem cells Metabolic liver zonation |
| url | http://www.sciencedirect.com/science/article/pii/S2589555923001106 |
| work_keys_str_mv | AT fengchen distincthepatocyteidentitiesinliverhomeostasisandregenerationkeypoints AT katharinaschonberger distincthepatocyteidentitiesinliverhomeostasisandregenerationkeypoints AT janstchorz distincthepatocyteidentitiesinliverhomeostasisandregenerationkeypoints |