Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

The major human apurinic/apyrimidinic endonuclease APE1 plays a pivotal role in the repair of base damage via participation in the DNA base excision repair (BER) pathway. Increased activity of APE1, often observed in tumor cells, is thought to contribute to resistance to various anticancer drugs, wh...

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Bibliographic Details
Main Authors: Dorjbal Dorjsuren, Daemyung Kim, Vaddadi N Vyjayanti, David J Maloney, Ajit Jadhav, David M Wilson, Anton Simeonov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3479139?pdf=render

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http://europepmc.org/articles/PMC3479139?pdf=render

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