Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies

Some antibodies exhibit elevated viscosity at high concentrations, making them poorly suited for therapeutic applications requiring administration by injection such as subcutaneous or ocular delivery. Here we studied an anti-IL-13/IL-17 bispecific IgG4 antibody, which has anomalously high viscosity...

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Bibliographic Details
Main Authors: Cholpon Tilegenova, Saeed Izadi, Jianping Yin, Christine S. Huang, Jiansheng Wu, Diego Ellerman, Sarah G. Hymowitz, Benjamin Walters, Cleo Salisbury, Paul J. Carter
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
Bispecific IgG
IgG
viscosity
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1692764

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2019.1692764

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