CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation

CRISPR-Cas9-mediated knockout of SPRY2 in human hepatocytes leads to increased glucose uptake and lipid droplet accumulation

Abstract Background The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome-wide association studies (GWAS) have identified hundreds of genec susc...

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Bibliographic Details
Main Authors: Naomi L. Cook, Milos Pjanic, Andrew G. Emmerich, Abhiram S. Rao, Susanne Hetty, Joshua W. Knowles, Thomas Quertermous, Casimiro Castillejo-López, Erik Ingelsson
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Endocrine Disorders
Subjects:
SPRY2
Obesity
Type 2 diabetes mellitus
Hepatocytes
Glucose metabolism
Lipid metabolism
Online Access:http://link.springer.com/article/10.1186/s12902-019-0442-8

Internet

http://link.springer.com/article/10.1186/s12902-019-0442-8

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