Multi-parametric hyperpolarized 13C/1H imaging reveals Warburg-related metabolic dysfunction and associated regional heterogeneity in high-grade human gliomas

Multi-parametric hyperpolarized 13C/1H imaging reveals Warburg-related metabolic dysfunction and associated regional heterogeneity in high-grade human gliomas

Background: Dynamic hyperpolarized (HP)-13C MRI has enabled real-time, non-invasive assessment of Warburg-related metabolic dysregulation in glioma using a [1-13C]pyruvate tracer that undergoes conversion to [1-13C]lactate and [13C]bicarbonate. Using a multi-parametric 1H/HP-13C imaging approach, we...

Full description

Bibliographic Details
Main Authors: Adam W. Autry, Sana Vaziri, Marisa LaFontaine, Jeremy W. Gordon, Hsin-Yu Chen, Yaewon Kim, Javier E. Villanueva-Meyer, Annette Molinaro, Jennifer L. Clarke, Nancy Ann Oberheim Bush, Duan Xu, Janine M. Lupo, Peder E.Z. Larson, Daniel B. Vigneron, Susan M. Chang, Yan Li
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:NeuroImage: Clinical
Subjects:
GBM
Hyperpolarized carbon-13
Metabolism
Treatment effects
IDH
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158223001924

Internet

http://www.sciencedirect.com/science/article/pii/S2213158223001924

Similar Items