Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST

Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST

Setting: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH).DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and...

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Bibliographic Details
Main Authors: Eliana Abreu Santos, José Carlos Saraiva Gonçalves, Marcos K. Fleury, Afrânio L. Kritski, Martha M. Oliveira, Luciane S. Velasque, José Roberto Lapa e Silva, Rita de Cássia E. Estrela
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Brazilian Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1413867019304453

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http://www.sciencedirect.com/science/article/pii/S1413867019304453

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