Intratumoral Injection of Large Surface Area Microparticle Taxanes in Carcinomas Increases Immune Effector Cell Concentrations, Checkpoint Expression, and Synergy with Checkpoint Inhibitors: A Review of Preclinical and Clinical Studies

Intratumoral Injection of Large Surface Area Microparticle Taxanes in Carcinomas Increases Immune Effector Cell Concentrations, Checkpoint Expression, and Synergy with Checkpoint Inhibitors: A Review of Preclinical and Clinical Studies

Abstract This review summarizes development of large surface area microparticle paclitaxel (LSAM-PTX) and docetaxel (LSAM-DTX) for local treatment of primary carcinomas with emphasis on immunomodulation. Intratumoral (IT) delivery of LSAM-PTX and LSAM-DTX provides continuous, therapeutic drug levels...

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Bibliographic Details
Main Authors: Gere S. diZerega, Holly A. Maulhardt, Shelagh J. Verco, Alyson M. Marin, Michael J. Baltezor, Samantha A. Mauro, Marc A. Iacobucci
Format: Article
Language:English
Published: Adis, Springer Healthcare 2024-01-01
Series:Oncology and Therapy
Subjects:
Paclitaxel
Docetaxel
Intratumoral injection
Intraprostatic injection
Intramural injection
Intravesical instillation
Online Access:https://doi.org/10.1007/s40487-024-00261-y

Internet

https://doi.org/10.1007/s40487-024-00261-y

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