Single-nucleus transcriptomic analysis reveals the relationship between gene expression in oligodendrocyte lineage and major depressive disorder

Single-nucleus transcriptomic analysis reveals the relationship between gene expression in oligodendrocyte lineage and major depressive disorder

Abstract Background Major depressive disorder (MDD) is a common mental illness that affects millions of people worldwide and imposes a heavy burden on individuals, families and society. Previous studies on MDD predominantly focused on neurons and employed bulk homogenates of brain tissues. This pape...

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Bibliographic Details
Main Authors: Yinping Xie, Lijuan Chen, Leimin Wang, Tongou Liu, Yage Zheng, Lujia Si, Hailong Ge, Hong Xu, Ling Xiao, Gaohua Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
Major depressive disorder
Oligodendrocyte lineage development
Single-cell transcriptome
Guided regularized random forest algorithm
MALAT1
Online Access:https://doi.org/10.1186/s12967-023-04727-x

Internet

https://doi.org/10.1186/s12967-023-04727-x

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