Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

Acquired immunodeficiency syndrome (AIDS) is one of the most challenging infectious diseases to treat on a global scale. Understanding the mechanisms underlying the development of drug resistance is necessary for novel therapeutics. HIV subtype C is known to harbor mutations at critical positions of...

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Bibliographic Details
Main Authors: Sankaran Venkatachalam, Nisha Murlidharan, Sowmya R. Krishnan, C. Ramakrishnan, Mpho Setshedi, Ramesh Pandian, Debmalya Barh, Sandeep Tiwari, Vasco Azevedo, Yasien Sayed, M. Michael Gromiha
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Genes
Subjects:
HIV protease subtype C
L38HL double insertion
Saquinavir
drug resistance
molecular dynamics simulations
Online Access:https://www.mdpi.com/2073-4425/14/2/533

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https://www.mdpi.com/2073-4425/14/2/533

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