Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A20

Dysregulation of the Intestinal Microbiome in Patients With Haploinsufficiency of A20

IntroductionHaploinsufficiency of A20 (HA20) is a form of inborn errors of immunity (IEI). IEIs are genetically occurring diseases, some of which cause intestinal dysbiosis. Due to the dysregulation of regulatory T cells (Tregs) observed in patients with HA20, gut dysbiosis was associated with Tregs...

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Main Authors: Etsushi Toyofuku, Kozue Takeshita, Hidenori Ohnishi, Yuko Kiridoshi, Hiroaki Masuoka, Tomonori Kadowaki, Ryuta Nishikomori, Kenichi Nishimura, Chie Kobayashi, Takasuke Ebato, Tomonari Shigemura, Yuzaburo Inoue, Wataru Suda, Masahira Hattori, Tomohiro Morio, Kenya Honda, Hirokazu Kanegane
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
haploinsufficiency of A20
intestinal microbiome
regulatory T cells
inborn errors of immunity
Streptococcus mutans
Lactobacillus salivarius
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.787667/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.787667/full

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