Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?

Prevalence of the Brazilian TP53 Founder c.1010G>A (p.Arg337His) in Lung Adenocarcinoma: Is Genotyping Warranted in All Brazilian Patients?

In Southern and Southeastern Brazil, there is a germline pathogenic variant with incomplete penetrance located in the oligomerization domain of TP53, c.1010G>A (p.Arg337His). Due to a founder effect, the variant is present in 0.3% of the general population of the region. Recently, this varian...

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Bibliographic Details
Main Authors: Igor Araujo Vieira, Tiago Finger Andreis, Bruna Vieira Fernandes, Maria Isabel Achatz, Gabriel S. Macedo, Daniel Schramek, Patricia Ashton-Prolla
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Genetics
Subjects:
TP53 gene
p53 protein
lung adenocarcinoma
founder variant
TP53 (p.Arg337His)
R337H
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.606537/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.606537/full

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