NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells

NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells

Disrupting lung tumor growth via histone deacetylases (HDACs) inhibition is a strategy for cancer therapy or prevention. Targeting HDAC6 may disturb the maturation of heat shock protein 90 (Hsp90) mediated cell cycle regulation. In this study, we demonstrated the effects of semisynthesized NBM-T-BBX...

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Bibliographic Details
Main Authors: Jih-Tung Pai, Chia-Yun Hsu, Kuo-Tai Hua, Sheng-Yung Yu, Chung-Yang Huang, Chia-Nan Chen, Chiung-Ho Liao, Meng-Shih Weng
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
histone deacetylase
heat shock protein 90
cell cycle arrest
NBM-T-BBX-OS01 (TBBX)
suberoylanilide hydroxamic acid (SAHA)
lung cancer
Online Access:http://www.mdpi.com/1420-3049/20/5/8000

Internet

http://www.mdpi.com/1420-3049/20/5/8000

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