A phosphodiesterase-4 inhibitor reduces lung inflammation and fibrosis in a hamster model of SARS-CoV-2 infection

A phosphodiesterase-4 inhibitor reduces lung inflammation and fibrosis in a hamster model of SARS-CoV-2 infection

IntroductionThe Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) infection involves pulmonary inflammation that can progress to acute respiratory distress syndrome, a primary cause of lung damage/fibrosis in patients with Coronavirus Disease-2019 (COVID-19). Currently, there is no effica...

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Bibliographic Details
Main Authors: Afsal Kolloli, Santhamani Ramasamy, Ranjeet Kumar, Annuurun Nisa, Gilla Kaplan, Selvakumar Subbian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
COVID-19
inflammation
cytokine storm
host-directed therapy
lung function
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270414/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270414/full

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