The CLC-5 2Cl-/H+ exchange transporter in endosomal function and Dent’s disease.
CLC-5 plays a critical role in the process of endocytosis in the proximal tubule of the kidney and mutations that alter protein function are the cause of Dent’s I disease. In this X-linked disorder impaired reabsorption results in the wasting of calcium and low molecular weight protein to the urine,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00449/full |