GABAA Receptor β2E155 Residue Located at the Agonist-Binding Site Is Involved in the Receptor Gating

GABAA Receptor β2E155 Residue Located at the Agonist-Binding Site Is Involved in the Receptor Gating

GABAA receptors (GABAARs) play a crucial role in mediating inhibition in the adult brain. In spite of progress in describing (mainly) the static structures of this receptor, the molecular mechanisms underlying its activation remain unclear. It is known that in the α1β2γ2L receptors, the mutation of...

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Bibliographic Details
Main Authors: Magdalena Jatczak-Śliwa, Magdalena Kisiel, Marta Magdalena Czyzewska, Marek Brodzki, Jerzy Władysław Mozrzymas
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GABAA receptor
orthosteric binding site
preactivation
structure–function
mutagenesis
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00002/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00002/full

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