Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice

Abstract The adverse effects of microgravity exposure on mammalian physiology during spaceflight necessitate a deep understanding of the underlying mechanisms to develop effective countermeasures. One such concern is muscle atrophy, which is partly attributed to the dysregulation of calcium levels d...

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Bibliographic Details
Main Authors: Kevin Li, Riya Desai, Ryan T. Scott, Joel Ricky Steele, Meera Machado, Samuel Demharter, Adrienne Hoarfrost, Jessica L. Braun, Val A. Fajardo, Lauren M. Sanders, Sylvain V. Costes
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:npj Microgravity
Online Access:https://doi.org/10.1038/s41526-023-00337-5