Australian Marine and Terrestrial <i>Streptomyces</i>-Derived Surugamides, and Synthetic Analogs, and Their Ability to Inhibit <i>Dirofilaria immitis</i> (Heartworm) Motility

Australian Marine and Terrestrial <i>Streptomyces</i>-Derived Surugamides, and Synthetic Analogs, and Their Ability to Inhibit <i>Dirofilaria immitis</i> (Heartworm) Motility

A bioassay-guided chemical investigation of a bacterium, <i>Streptomyces</i> sp. CMB-MRB032, isolated from sheep feces collected near Bathurst, Victoria, Australia, yielded the known polyketide antimycins A4a (<b>1</b>) and A2a (<b>2</b>) as potent inhibitors of &...

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Bibliographic Details
Main Authors: Taizong Wu, Waleed M. Hussein, Kaumadi Samarasekera, Yuxuan Zhu, Zeinab G. Khalil, Shengbin Jin, David F. Bruhn, Yovany Moreno, Angela A. Salim, Robert J. Capon
Format: Article
Language:English
Published: MDPI AG 2024-07-01
Series:Marine Drugs
Subjects:
antimycins
surugamides
acyl-surugamides
anthelmintic
heartworm
<i>Dirofilaria immitis</i>
Online Access:https://www.mdpi.com/1660-3397/22/7/312

Internet

https://www.mdpi.com/1660-3397/22/7/312

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