Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

Abstract Background Amyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. Our study was aimed to uncover new connections within the ALS netw...

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Bibliographic Details
Main Authors: S. Beltran, M. Nassif, E. Vicencio, J. Arcos, L. Labrador, B. I. Cortes, C. Cortez, C. A. Bergmann, S. Espinoza, M. F. Hernandez, J. M. Matamala, L. Bargsted, S. Matus, D. Rojas-Rivera, M. J. M. Bertrand, D. B. Medinas, C. Hetz, P. A. Manque, U. Woehlbier
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Molecular Neurodegeneration
Subjects:
ALS
Autophagy
Beclin1
C13orf18, KIAA0226-like
Pacer
Rubicon
Online Access:http://link.springer.com/article/10.1186/s13024-019-0313-9

Internet

http://link.springer.com/article/10.1186/s13024-019-0313-9

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