Inhibitory Effect of Azimilide on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Myocytes
We examined the effect of azimilide, a class III antiarrhythmic drug, on Na+/Ca2+ exchange current (INCX) in guinea-pig cardiac single ventricular cells. External application of azimilide suppressed bi-directional INCX in a concentration-dependent manner. IC50 values for outward and inward INCX were...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2010-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319308874 |