Enhancing the Cytotoxicity and Apoptotic Efficacy of Parasporin-2-Derived Variants (Mpp46Aa1) on Cancer Cell Lines

Parasporin PS2Aa1, recently renamed Mpp46Aa1, is an anti-cancer protein known for its selectivity against various human cancer cell lines. We genetically modified native PS2Aa1 to create a library of approximately 100 mutants. From this library, we selected promising mutants based on their half-maxi...

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Bibliographic Details
Main Authors: Juan S. Alarcón-Aldana, Lydia Visser, Nohora J. Rueda-Forero, Efraín H. Pinzón-Reyes, Paola Rondón-Villarreal, Miguel O. Suárez-Barrera
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/16/10/415