Overexpression of satellite RNAs in heterochromatin induces chromosomal instability and reflects drug sensitivity in mouse cancer cells

Overexpression of satellite RNAs in heterochromatin induces chromosomal instability and reflects drug sensitivity in mouse cancer cells

Abstract Overexpression of satellite RNAs in heterochromatin induces chromosomal instability (CIN) through the DNA damage response and cell cycle checkpoint activation. Although satellite RNAs may be therapeutic targets, the associated mechanisms underlying drug sensitivity are unknown. Here, we det...

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Bibliographic Details
Main Authors: Sawako Tamaki, Koichi Suzuki, Iku Abe, Yuhei Endo, Nao Kakizawa, Fumiaki Watanabe, Masaaki Saito, Shingo Tsujinaka, Yasuyuki Miyakura, Satoshi Ohta, Kenji Tago, Ken Yanagisawa, Fumio Konishi, Toshiki Rikiyama
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15071-3

Internet

https://doi.org/10.1038/s41598-022-15071-3

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