Differential Interferon Signaling Regulation and Oxidative Stress Responses in the Cerebral Cortex and Cerebellum Could Account for the Spatiotemporal Pattern of Neurodegeneration in Niemann–Pick Disease Type C

Differential Interferon Signaling Regulation and Oxidative Stress Responses in the Cerebral Cortex and Cerebellum Could Account for the Spatiotemporal Pattern of Neurodegeneration in Niemann–Pick Disease Type C

Niemann–Pick disease type C (NPC) is a fatal neurodegenerative condition caused by genetic mutations of the <i>NPC1</i> or <i>NPC2</i> genes that encode the NPC1 and NPC2 proteins, respectively, which are believed to be responsible for cholesterol efflux from late-endosomes/l...

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Bibliographic Details
Main Authors: Andrew J. Tolan, Kayla L. Sanchez, Samuel D. Shin, Jacob B. White, Antonio Currais, David Soriano-Castell, Christopher G. Wilson, Pamela Maher, Salvador Soriano
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Genes
Subjects:
Niemann–Pick disease type C
neurodegeneration
interferon signaling
Online Access:https://www.mdpi.com/2073-4425/15/1/101

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https://www.mdpi.com/2073-4425/15/1/101

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