Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

Activation of glucocorticoid receptor signaling inhibits KSHV-induced inflammation and tumorigenesis

ABSTRACTHyperinflammation is the hallmark of Kaposi’s sarcoma (KS), the most common cancer in AIDS patients caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) infection. However, the role and mechanism of induction of inflammation in KS remain unclear. In a screening for inhibitors of KSHV-ind...

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Bibliographic Details
Main Authors: Luping Chen, Ling Ding, Xian Wang, Yufei Huang, Shou-Jiang Gao
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
Kaposi’s sarcoma (KS)
Kaposi’s sarcoma-associated herpesvirus (KSHV)
inflammation
dexamethasone
glucocorticoid receptor (GR) signaling
interleukin-1 alpha (IL-1α)
Online Access:https://journals.asm.org/doi/10.1128/mbio.03011-23

Internet

https://journals.asm.org/doi/10.1128/mbio.03011-23

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