ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape

ZNF521 Enhances MLL-AF9-Dependent Hematopoietic Stem Cell Transformation in Acute Myeloid Leukemias by Altering the Gene Expression Landscape

Leukemias derived from the MLL-AF9 rearrangement rely on dysfunctional transcriptional networks. ZNF521, a transcription co-factor implicated in the control of hematopoiesis, has been proposed to sustain leukemic transformation in collaboration with other oncogenes. Here, we demonstrate that ZNF521...

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Bibliographic Details
Main Authors: Emanuela Chiarella, Annamaria Aloisio, Stefania Scicchitano, Katia Todoerti, Emanuela G. Cosentino, Daniela Lico, Antonino Neri, Nicola Amodio, Heather Mandy Bond, Maria Mesuraca
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia (AML)
cord blood-derived hematopoietic stem cells (CB-CD34<sup>+</sup>)
human zinc finger protein 521 (hZNF521)
mixed lineage leukemia gene (MLL) AF9 (MLLT3 or LTG9)
fusion gene MLL-AF9
chromosomal translocations
Online Access:https://www.mdpi.com/1422-0067/22/19/10814

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https://www.mdpi.com/1422-0067/22/19/10814

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