Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor.

Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor.

Myocardial depression is an important contributor to mortality in sepsis. We have recently demonstrated that α2-adrenoceptor (AR) antagonist, yohimbine (YHB), attenuates lipopolysaccharide (LPS)-induced myocardial depression. However, the mechanisms for this action of YHB are unclear. Here, we demon...

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Bibliographic Details
Main Authors: Yiyang Wang, Xiaohui Yu, Faqiang Wang, Yuan Wang, Yanping Wang, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3653853?pdf=render

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http://europepmc.org/articles/PMC3653853?pdf=render

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