Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidines as Microtubule Targeting Agents

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidines as Microtubule Targeting Agents

A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-<i>d</i>]pyrimidines were designed and synthesized and their biological activities were evaluated. Synthesis involved the Gewald reaction to synthesize ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate...

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Bibliographic Details
Main Authors: Farhana Islam, Arpit Doshi, Andrew J. Robles, Tasdique M. Quadery, Xin Zhang, Xilin Zhou, Ernest Hamel, Susan L. Mooberry, Aleem Gangjee
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
microtubules
colchicine site
microtubule targeting agents
Gewald reaction
Online Access:https://www.mdpi.com/1420-3049/27/1/321

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https://www.mdpi.com/1420-3049/27/1/321

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