Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers

Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers

There has been a gradual increase in 16S deep sequencing studies on infectious disease materials. Management of bacterial DNA contamination is a major challenge in such diagnostics, particularly in low biomass samples.

Bibliographic Details
Main Authors: Ruben Dyrhovden, Martin Rippin, Kjell Kåre Øvrebø, Randi M. Nygaard, Elling Ulvestad, Øyvind Kommedal
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00598-21

Internet

https://journals.asm.org/doi/10.1128/mBio.00598-21

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