Induction of resistance to neurotrophic tropomyosin‐receptor kinase inhibitors by HMGCS2 via a mevalonate pathway

Induction of resistance to neurotrophic tropomyosin‐receptor kinase inhibitors by HMGCS2 via a mevalonate pathway

Abstract Introduction A neurotrophic tropomyosin receptor kinase (NTRK)‐tyrosine kinase inhibitor (TKI) has shown dramatic efficacy against malignant tumors harboring an NTRK fusion gene. However, almost all tumors eventually acquire resistance to NTRK‐TKIs. Method To investigate the mechanism of re...

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Bibliographic Details
Main Authors: Yasuhiro Kato, Masaru Matsumoto, Natsuki Takano, Mariko Hirao, Kuniko Matsuda, Takehiro Tozuka, Naomi Onda, Shinji Nakamichi, Susumu Takeuchi, Akihiko Miyanaga, Rintaro Noro, Akihiko Gemma, Masahiro Seike
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:Cancer Medicine
Subjects:
HMGCS2
mevalonate pathway
NTRK‐TKI
resistance mechanism
statin
Online Access:https://doi.org/10.1002/cam4.7393

Internet

https://doi.org/10.1002/cam4.7393

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