6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

Liver aging is associated with age-related histopathological and functional changes that significantly enhance the risk of numerous diseases or disorders developing in elderly populations. 6-Bromoindirubin-3′-oxime (6BIO), a potent inhibitor of glycogen synthase kinase-3 (GSK-3), has been implicated...

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Bibliographic Details
Main Authors: Donghao Guo, Yun Shen, Wei Li, Qinjie Li, Yu Zhao, Chenhao Pan, Bi Chen, Yuan Zhong, Ya Miao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
6-bromoindirubin-3′-oxime
aging
autophagy
mammalian target of rapamycin
glycogen synthase kinase-3β
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00320/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00320/full

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