A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

A human-based multi-gene signature enables quantitative drug repurposing for metabolic disease

Insulin resistance (IR) contributes to the pathophysiology of diabetes, dementia, viral infection, and cardiovascular disease. Drug repurposing (DR) may identify treatments for IR; however, barriers include uncertainty whether in vitro transcriptomic assays yield quantitative pharmacological data, o...

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Bibliographic Details
Main Authors: James A Timmons, Andrew Anighoro, Robert J Brogan, Jack Stahl, Claes Wahlestedt, David Gordon Farquhar, Jake Taylor-King, Claude-Henry Volmar, William E Kraus, Stuart M Phillips
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
drug repurposing
insulin biology
deep learning
Diabetes
Transcriptomics
Exercise
Online Access:https://elifesciences.org/articles/68832

Internet

https://elifesciences.org/articles/68832

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